Daichi Morimoto

Water in the body, including blood, generally flows with a specific direction. This flow applies stress to solute proteins, leading to their structural disruption. Although the structural disruption is associated with various life events such as homeostasis maintenance and disease development, the general and quantitative properties of structural disruption remain elusive. In this study, we analyze structural disruption of proteins with high spatiotemporal resolution and establish a theory to comprehend and predict the structural disruption.

We plan to establish a cooperative research system that combines rheological NMR, MD, and SAXS, which are novel analytical methods integrating structural biology and rheology. We will then quantitatively investigate the structural disruption of blood and intracellular proteins by hydrodynamic stress in situ and on an atomic- to meso-scale. This study aims to elucidate the regularity, reversibility, and linearity of structural disruption, and formulate and theorize them to construct a new scientific doctrine, "Protein Fluid Dynamics".